Decatenation: fixing your knots.
نویسنده
چکیده
How tumor cells gain resistance to drugs is critically important to elucidate for developing better cancer therapy. In this issue of Blood, Wray and colleagues have identified a mechanism whereby acute leukemia cells use a stimulator of topoisomerase II activity to allow proliferation despite drug inhibition of this essential enzyme.
منابع مشابه
DNA supercoiling and its role in DNA decatenation and unknotting
Chromosomal and plasmid DNA molecules in bacterial cells are maintained under torsional tension and are therefore supercoiled. With the exception of extreme thermophiles, supercoiling has a negative sign, which means that the torsional tension diminishes the DNA helicity and facilitates strand separation. In consequence, negative supercoiling aids such processes as DNA replication or transcript...
متن کاملSURVEY AND SUMMARY DNA supercoiling and its role in DNA decatenation and unknotting
Chromosomal and plasmid DNA molecules in bacterial cells are maintained under torsional tension and are therefore supercoiled. With the exception of extreme thermophiles, supercoiling has a negative sign, which means that the torsional tension diminishes the DNA helicity and facilitates strand separation. In consequence, negative supercoiling aids such processes as DNA replication or transcript...
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DNA topology plays a crucial role in all living cells. In prokaryotes, negative supercoiling is required to initiate replication and either negative or positive supercoiling assists decatenation. The role of DNA knots, however, remains a mystery. Knots are very harmful for cells if not removed efficiently, but DNA molecules become knotted in vivo. If knots are deleterious, why then does DNA bec...
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Distinguishing Physical and Mathematical Knots and Links Joel Hass (joint work with Alexander Coward ) The theory of knots and links studies one-dimensional submanifolds of R. These are often described as loops of string, or rope, with their ends glued together. Real ropes however are not one-dimensional, but have a positive thickness and a finite length. Indeed, most physical applications of k...
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It is shown that for any locally knotted edge of a 3-connected graph in S^3, there is a ball that contains all of the local knots of that edge and it is unique up to an isotopy setwise fixing the graph. This result is applied to the study of topological symmetry groups of graphs embedded in S^3. Response to Reviewers: See attachment. SPATIAL GRAPHS WITH LOCAL KNOTS ERICA FLAPAN, BLAKE MELLOR, A...
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ورودعنوان ژورنال:
- Blood
دوره 114 9 شماره
صفحات -
تاریخ انتشار 2009